Cavity Binding

De Genst E, Silence K, Decanniere K, Conrath K, Loris R, Kinne J, Muyldermans S, Wyns L.  Molecular basis for the preferential cleft recognition by dromedary heavy-chain antibodies.  Proc Natl Acad Sci U S A. 2006 Mar 21; 103 (12): 4586-91.

Marquardt A, Muyldermans S, Przybylski M.  A synthetic camel anti-lysozyme peptide antibody (peptibody) with flexible loop structure identified by high-resolution affinity mass spectrometry.  Chemistry. 2006 Feb 20; 12 (7): 1915-23.

Spinelli S, Desmyter A, Verrips CT, de Haard HJ, Moineau S, Cambillau C.  Lactococcal bacteriophage p2 receptor-binding protein structure suggests a common ancestor gene with bacterial and mammalian viruses.  Nat Struct Mol Biol. 2006 Jan; 13 (1): 85-9.

Gibbs WW.  Nanobodies.  Sci Am. 2005 Aug; 293 (2): 78-83.

Ledeboer AM, Bezemer S, de Haard JJ, Schaffers IM, Verrips CT, van Vliet C, Dusterhoft EM, Zoon P, Moineau S, Frenken LG.  Preventing phage lysis of Lactococcus lactis in cheese production using a neutralizing heavy-chain antibody fragment from llama.  J Dairy Sci. 2002 Jun; 85(6):1376-82.

Desmyter A, Spinelli S, Payan F, Lauwereys M, Wyns L, Muyldermans S, Cambillau C.  Three camelid VHH domains in complex with porcine pancreatic alpha-amylase.  J Biol Chem. 2002 Jun 28; 277 (26): 23645-50.1376-82.

Conrath KE, Lauwereys M, Galleni M, Matagne A, Frère JM, Kinne J, Wyns L, Muyldermans S.  Beta-lactamase inhibitors derived from single-domain antibody fragments elicited in Camelidae.  Antimicrob Agents Chemother. 2001 Oct; 45 (10): 2807-12.

Desmyter A, Decanniere K, Muyldermans S, Wyns L.  Antigen specificity and high affinity binding provided by one single loop of a camel single-domain antibody.  J Biol Chem. 2001 Jul 13 ;276 (28): 26285-90.

Muyldermans S.  Single domain camel antibodies: current status.  J Biotechnol. 2001 Jun; 74 (4): 277-302.

Decanniere K, Desmyter A, Lauwereys M, Ghahroudi MA, Muyldermans S, Wyns L.  A single-domain antibody fragment in complex with Rnase A: non canonical loop structures and nanomolar affinity using two CDR loops.  Structure Fold Des. 1999 Apr 15; 7(4): 361-70.

Transue TR, De Genst E, Ghahroudi MA, Wyns L, Muyldermans S.  Camel single-domain antibody inhibits enzyme by mimicking carbohydrate substrate.  Proteins 1998 Sep 1; 32(4): 515-22.

Lauwereys M, Ghahroudi MA, Desmyter A, Kinne J, Hölzer W, De Genst E, Wyns L, Muyldermans S.  Potent enzyme inhibitors derived from dromedary heavy-chain antibodies.  EMBO J. 1998 Jul 1; 17(13): 3512-20.

Desmyter A, Transue TR, Ghahroudi MA, Thi MH, Poortmans F, Hamers R, Muyldermans S, Wyns L.  Crystal structure of a camel single-domain VH antibody fragment in complex with lysozyme.  Nat Struct Biol. 1996 Sep; 3(9): 803-11.

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