High Affinity

Coppieters K, Dreier T, Silence K, Haard HD, Lauwereys M, Casteels P, Beirnaert E, Jonckheere H, Wiele CV, Staelens L, Hostens J, Revets H, Remaut E, Elewaut D, Rottiers P.  Formatted anti-tumor necrosis factor alpha VHH proteins derived from camelids show superior potency and targeting to inflamed joints in a murine model of collagen-induced arthritis.  Arthritis Rheum. 2006 Jun; 54 (6): 1856-66.

Huang L, Reekmans G, Saerens D, Friedt JM, Frederix F, Francis L, Muyldermans S, Campitelli A, Van Hoof C.  Prostate-specific antigen immunosensing based on mixed self-assembled monolayers, camel antibodies and colloidal gold enhanced sandwich assays.  Biosens Bioelectron. 2005 Sep 15; 21(3):483-90.

Gibbs WW.  Nanobodies.  Sci Am. 2005 Aug; 293 (2): 78-83.

De Genst E, Silence K, Ghahroudi MA, Decanniere K, Loris R, Kinne J, Wyns L, Muyldermans S.  Strong in vivo maturation compensates for structurally restricted H3 loops in antibody repertoires.  J Biol Chem. 2005 Apr 8; 280 (14): 14114-21.

Saerens D, Kinne J, Bosmans E, Wernery U, Muyldermans S, Conrath K.  Single domain antibodies derived from dromedary lymph node and peripheral blood lymphocytes sensing conformational variants of prostate-specific antigen.  J Biol Chem. 2004 Dec 10; 279 (50): 51965-72.

Muyldermans S.  Single domain camel antibodies: current status.  J Biotechnol. 2001 Jun; 74 (4): 277-302.

Frenken LG, van der Linden RH, Hermans PW, Bos JW, Ruuls RC, de Geus B, Verrips CT.  Isolation of antigen specific llama VHH antibody fragments and their high level secretion by Saccharomyces cerevisiae.  J Biotechnol. 2000 Feb 28; 78(1): 11-21.

Lauwereys M, Ghahroudi MA, Desmyter A, Kinne J, Hölzer W, De Genst E, Wyns L, Muyldermans S.  Potent enzyme inhibitors derived from dromedary heavy-chain antibodies.  EMBO J. 1998 Jul 1; 17(13): 3512-20.

Arbabi Ghahroudi M, Desmyter A, Wyns L, Hamers R, Muyldermans S.  Selection and identification of single domain antibody fragments from camel heavy-chain antibodies.  FEBS Lett. 1997 Sep 15; 414(3): 521-6.

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