ALX-0141 – anti-RANKL Nanobody to treat bone-loss related disorders 

  • ALX-0141 is being developed for the treatment of bone-loss related disorders including osteoporosis and bone metastasis
  • ALX-0141 successfully completed a Phase I study in post-menopausal women
  • Exclusive license agreement signed with Eddingpharm in October 2013 to develop and commercialise ALX-0141 in Mainland China, Hong Kong, Macao and Taiwan
  • Ablynx is not pursuing this programme internally and is looking for licensing opportunities outside Greater China

Osteoporosis and Bone Metastasis

Osteoporosis is a progressive bone disease characterised by a decrease in bone mass and density which can lead to an increased risk for fractures. Bone metastasis, or metastatic bone disease, is a class of cancer metastases that results from primary tumor invasion to bone. Unlike haematological malignancies that originate in the blood and form non-solid tumours, bone metastasis generally arise from epithelial tumors and form a solid mass inside the bone.

ALX-0141 mode of action

ALX-0141 (41kD) specifically targets RANKL, a key mediator of bone resorption and an essential regulator of osteoclasts, the cells involved in the breakdown of bone. ALX-0141 is a trivalent Nanobody targeting RANKL and that binds to serum albumin to increase its in vivo half-life.

Partnering opportunity

Ablynx is currently looking for partners to develop and commercialise ALX-0141 outside of Greater China. For further information, please contact Gosia Ciesiolka, Director Business Development.

Related presentations, abstracts and posters

Presentation at ECTS 2012: ALX-0141 increases bone mass in cynomolgus monkeys

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