Ablynx’s Nanobodies combine the advantages of conventional antibodies with important features of small molecule drugs.
Like conventional antibodies, Nanobodies show:
- high target specificity
- high affinity for their target
- low inherent toxicity.
However, like small molecule drugs they have the opportunity to inhibit enzymes and readily access receptor clefts, which is challenging with conventional antibodies.
- are generally very stable
- have the potential to be administered by means other than injection
- are easy to manufacture.
To reduce the risk of immunogenicity, Ablynx routinely humanizes its Nanobodies. This is a straightforward procedure because Nanobodies already display relatively high sequence homology to human heavy chain variable domains, typically between 80% and 90% when comparing the framework regions.